[4] AF dosage dependent
Even at a higher AF ingestion, low protein diet still show lower foci (pre-cancer) formation than the high protein diet. #33, #34. Chart1
Chart 1: Low AF yet High Dietary Protein shows more pre-cancer than High AF yet lower-protein Diet.
Chart 2: High-protein diet shows AF response curve to AF-dosage. No such response curve is seen at low protein diet.
#33. Appleton BS and Campbell TC, "Inhibition of Aflatoxin-initiated preneoplastic liver lesion by low dietary protein" Nutr Cancer 3 (1982). 200-206.
#34 Dunaif GE Nd Campbell TC, "Relative Contribution of Dietary Protein Level and Aflatoxin B1 dose in generation of presumptive preneoplastic foci in rat liver." J Natl Cancer Inst. 78 (1987) 365-369
[5] Low Protein Diet can reverse the course of the cancer, yet high protein diet can turn on dormant cancer cell.
Rats that ingested with AF were first fed with 20% protein for 6 weeks. Foci appeared in this 6 weeks. When they were fed with 5% protein starting at 7 weeks, they showed the shrinkage of foci. #35
Rats that ingested with AF were fed with 5% protein for the first 6 weeks. They showed no signs of foci development. When they began to consume 20% protein starting at 7th week, foci appeared. #35
#35 Youngman LD and Campbell TC, "High protein intake promotes the growth of preneoplastic foci in Fischer #344 rat. Evidence that early remodeled foci retain the potential for future growth". J Nutr 121 (1991) 1454-1461.
[6] Plant protein does not have the same detrimental effect as the animal protein.
Soy or wheat protein, even at a 20% level did not make rats to form foci. #42, Chart 3
Chart 3: Soy Protein even fed with 20% level does not show cancer promotion
#42 Schulsinger DA, Root, MM; and Campbell TC "Effects of dietary protein quality on development of AF B1 induced hepatic preneoplastic lesions ". J Natl Cancer Inst 81, (1989): 1241-1245
Rats undergone 100 week period. All rats were ingested with AF. Those rats who were fed with 20% protein were all dead at the end of the study. No sign of cancer fo rats who were fed with 5% protein. #36, #43, Chart 3.9A, 3.9B.
36. Youngman LD and Campbell TC "Inhibition of Aflatoxin B1-induced gamma-glutamyl transpeptidase positive (GGT+) hepatic preneoplastic foci & tumors by low protein diets: evidence that altered GGT+ foci indicate neoplasticism potential" Carcinogenesis B (1992) 1607-1613
43. Youngman LD "The growth and development of aflatoxin B1-induced preneoplastic lesions, tumors, metastasis, and spontaneous tumors as they are influenced by dietary protein level, type, and intervention. Ithaca, NY Cornell U Ph D Thesis 1990
[7] Dietary Protein Daily Consumption Recommendation
Dietary protein less than 10% has lower rate of tumor formation. #37. It means 50 gm of animal protein per day which is about 1 egg only per day. Any amount higher than 10% would be detrimental.
37. Duncif GE and Campbell TC , "Dietary Protein Level & Aflatoxin B1-induced preneoplastic hepatic lesions in the rats". J Nutrition 117 (1987) 1298-1302
[8] HBV Studies
These studies were done with transgenic mice that already have HBV presence. Some of them will develop liver cancer while others not depending on the protein diet.
Transgenic rats that are inherited with HBV gene showed hepatic cancer when fed with 22% protein; less intense cancer with 14% protein; and none with 6% protein. Chart 4. 5. # 47,48
Chart 4 HBV gene can be turned on or off depending on level of protein diet
Chart 5 Degree of liver tumors on mice depends on level of dietary protein
#47 Hu J., Cheng, Z., King J., et al "Repression of hepatitis B virus (HBV) transgene and HBV-induced liver injury by low protein diet." Oncogen 15 (1997): 2795-2801
#48 Cheng Z., Hu, J., King J., et al "Inhibition of hepatocellular carcinoma development in heptitis B virus transfected mice by low dietary casein" Hepatology 26 (1997) 1351-1354.
[9] DBMA and NMU Studies
Those two substances are experimental carcinogens. Similar results were found on comparing cancer incidences between high-protein diet versus low-protein diet. # 49-51
#49 Hawrylewicz EJ, Huang HH, Kissane JQ. et al "Enhancement of the 7,12-dimethylbenz(a)anthracene (DMBA) mammary tumorigenesis by high dietary protein in rats" Nutr. Int. 26 (1982) 793-806
#50 Hawrylewicz EJ, "Fat-protein interaction, defined by 2-generation studies." In C. Ip, D.E. Birt, A.E. Rogers and C. Mettlin (eds.) Dietary fat and cancer pp 403-434. New York: Alan R Liss Inc, 1986
#51 Huang HH, Hawrylewicz EJ, Kissane JQ, et al. "Effect of protein diet on release of proclatin and ovarian steroids in female rats." Nutr. Rpts. Int 26 (1982): 807-820
[10] Nitrite vs. Protein
When MIT researchers reported in Science in 1979 (#15) about the carcinogenesis of nitrite, the public reacted by not eating 'hot dogs'. In that report, the rats fed with excess of nitrite had cancer incidences of 10.2% versus rats with no nitrite of cancer case of 5.4% . It is only 10.2% versus 5.4% that is enough to brought to public attention.
#15. Nitrate story, Newberne, P., "Nitrites promote lymphoma incidence in rats." Science, 204, ( 1979), 1079-1081; 10.2% vs. 5.4%.
However, in terms of high protein diet, the statistics is 100% to 0% (Chart 6, and Reference 16)
Chart 6, 100 week of feeding of 22% protein diet, Rats are all dead.
# 16. Indian research on dietary protein, its effect on cancer. Madhaven, TV, Gopalan, C., Arch Path 85, 1968, 133-137. "Effect of dietary protein on the carcinogenesis of aflatoxin.
[11] Vegetarian Diet does not have to sacrifice the good taste
After reading those original publications, I began to change my diet; and it doesn't have to sacrifice with the good taste. Let me show you my typical plate for lunch in the following chart:
The top bowl is a vegetable soup with Kale, brocklie, carrort, mushroom, and tomotto in a broth of miso and pepper. The lower left, I have onions, radish, garlic, coconut flakes, avocado, and self-fermented sauerkraft. On the lower right are strawberry, grapes, sweetpepper, sliced apples on salad green.
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